Targin (Oxycodone + Naloxone)
- Effective for moderate to severe pain.
- Combination with naloxone reduces opioid-induced constipation.
- Naloxone component has minimal systemic absorption when taken orally.
Risks:
- Similar to those of oxycodone: dependence, nausea, constipation (though reduced), dizziness, and drowsiness.
- Risk of withdrawal symptoms if used in patients with opioid dependence.
- Naloxone can precipitate withdrawal in opioid-dependent patients if crushed and injected.