Panadeine Forte (Paracetamol 500mg + Codeine 30mg)
- Effective for moderate to severe pain.
- Combination of paracetamol and codeine provides synergistic pain relief.
Risks:
- Beware taking this with Paracetamol ( Do not take at the same time)
- Potential for dependence and abuse (codeine is an opioid).
- Common side effects include constipation, nausea, and dizziness.
- Eat lots of fibre and fluids and stop the medication as soon as possible
- Risk of hepatotoxicity from paracetamol component if taken in excess.
Genetic variability in codeine metabolism can lead to differences in efficacy and risk of overdose.
- Poor Metabolizers do not convert codeine to morphine effectively and thus experience little to no analgesic effect from codeine.
- This group represents approximately 5-10% of Caucasians, 1-2% of East Asians, and 1-10% of African Americans and Africans.
https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&id=CP-2010-CMI-05157-3